Quote from: FASANO, A.

Intestinal zonulin: open sesame!
Gut, 2001;49;159-162

It has recently been reported that untreated CD predisposes to autoimmune disorders such as insulin dependent diabetes mellitus, Hashimoto's thyroiditis, autoimmune hepatitis, and connective tissue diseases.28 One could hypothesise that zonulin opens small intestinal TJs during the early stages of CD and permits entry of putative allergens into the intestinal submucosa where an autoimmune response is elicited.

Alterations in intestinal TJ permeability